The impact of job-demands and resources on employees’ burnout, and employees’ well-being are an under-studied area in Pakistan. This study investigates the impact of job demands-resources model on burnout and well-being, based on a sample of 352 responses from the pharmaceutical companies of Karachi, using a cross-sectional research design. The JD-R model includes workload, autonomy, work-life imbalance, time pressure, and feedback. The measurement model shows very good composite reliability in addition to construct, convergent and discriminant validity. The structural equation modelling (SEM) method is used to test the six hypotheses. The results reveal that only three JD-R variables (i.e. workload, autonomy, and work-life imbalance) have significant impact on burnout (with the exception of time pressure and feedback) in the pharmaceutical sector of Karachi. Moreover, burnout has also shown a significant negative impact on the well-being of employees. The SEM analysis reflects a very good model fit with the sample drawn. Both managerial implications and areas for future research are discussed. This study makes a unique contribution in empirically testing the application of the JD-R model, particularly in the context of pharmaceutical companies of Karachi in Pakistan.
